https://www.alive.com/health/the-top-9-antiviral-essential-oils This post may contain special links through which we earn a small commission if you make a purchase (though your price is the same). 2 In this current SARS‐CoV‐2 pandemic, there has been a … Melaleuca cajuputi (Figure 1) is one of hundreds species of Melaleuca genus (Myrtaceae family) that is commonly grown in Vietnam, Indonesia, and Thailand.3 Melaleuca cajuputi can be used as fuelwood, piles and frame poles in construction. This research is supported by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 02/2020/ĐX. Gderrin 10:02, 9 September 2015 (UTC) References This page was last edited on 17 February 2019, at 09:19 (UTC). antimicrobial (i.e., antibiotic, antiviral, antiprotozoal, antifungal) and anti-inflammatory properties. Tea tree oil is an increasingly popular essential oil used in alternative medicine. Manufacturer of Essential Oil - Ajowan Oil, Bergamot Oil, Black Pepper Oil and Cajuput Oil offered by Ayuroma Centre, Kanpur, Uttar Pradesh. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, XXII International Symposium on Homogeneous Catalysis, I have read and accept the Wiley Online Library Terms and Conditions of Use, slct202000822-sup-0001-misc_information.pdf. Ca… It can be used for making up topical or inhaled medications.,[18][19] Therefore, we recognize that the results will support future research for the use of α-terpineol in the SARS-CoV-2 prevention. Inhibitory effect of essential oils against herpes simplex virus type 2. Its flowers attract honey bees.4 Its timber is used for pulp and paper, fiber and particle board. Terpineol (TA2), Guaiol (TA5), and Linalool (TA19) docked with ACE2 and PDB6LU7 proteins in the range of TA2 ≈ TA5 ≈ TA19; (A) Native human angiotensin converting enzyme 2 (ACE2) crystal structure. The results indicate that the 10 compounds (identification details in Table 1 and Figure S1 in the Supporting Information Summary) have the strongest interactions on the selected proteins that are the ones with the most powerful inhibitory activity for SAR-CoV-2. The antiviral effect of Olbas, a traditionally used complex essential oil, and of cajuput oil, a major constitutent of Olbas, against HSV type 1 was examined. The antiviral activity of these essential oils was tested in vitro on monkey kidney cells using a plaque reduction assay. (If the coconut oil is … Clove is a plant grown in parts of Asia and South America. However β-caryophyllene revealed a SI of 140, which is in the same range as the index value of 160 for star anise oil and is found in many different essential oils from different plant families. Oil of cajuput. Slide {current_page} of {total_pages} - You May Also Like. Based on the docking simulation results analyzed above, the interaction order of the compounds in the cajeput essential oil is listed as follows: TA2 ≈ TA5 ≈ TA19 > TA1 > TA3 > TA4 > TA7 > TA10 > TA18 > TA17. Chemotherapy. 2008 Jan;15(1-2):71-8. doi: 10.1016/j.phymed.2007.09.003. The three substances Terpineol (TA2), Guaiol (TA5), and Linalool (TA19) have the strongest inhibitory effects on ACE2 and PDB6LU7 proteins. Given the abundant supply in Vietnam and the specific healing properties of Melaleuca cajuputi,2 we recommend a solution for prevention of SARS-CoV-2 by using cajeput essential oil. National Library of Medicine The … Docking simulation results indicated the active bonding sites of 10 (TA1-TA5, TA7, TA10, TA17 – TA19) out of 24 compounds of the Melaleuca cajuputi essential oil are capable of inhibiting ACE2 and resisting PDB6LU7 protein in SARS-CoV-2. Interestingly, the synergistic interactions of these 10 substances of the TA exhibit excellent inhibition into the ACE2 and PDB6LU7 proteins. The fact is that cajeput essential oil is proved to have antifungal, anti-inflammatory, antioxidant activities.,[2],[8][11] According to some folk remedies, people use cajeput oil to help increase resistance, inhibit some bacteria and viruses, freshen air in the room, which are useful for providing postnatal care to women and newborns.2 In this current SARS-CoV-2 pandemic, there has been a great demand for preventive and curative vaccines as well as measures to prevent and stop the spread of the disease. Hydrogen bonds, ion bonds, arene – arene (π - π), cation-arenes (cations - π), and van der Waals interactions are detected by contacts with hydrophilic, hydrophobic, and solvent interaction. It is most commonly used to promote fin and tissue regrowth, but is also effective in treating other conditions, such as fin rot or velvet. Look it up now! Considering the lipophilic nature of the Olbas complex essential oil mixture, which enables it to penetrate the skin, and a high selectivity index, Olbas might be suitable for topical treatment of herpetic infections. The above results can affirm that the strongest interactions of the most active compounds of cajeput essential oil with the ACE2 and PDB6LU7 proteins are described in this order: TA2 ≈ TA5 ≈ TA19 > TA1 > TA3 > TA4 > TA7. Therefore, they are crucial for the use of the cajeput essential oil in preventing viruses that cause flu, pneumonia in general and the SARS-CoV-2 in specific. The docking results of TA10-ACE2 exhibit DS=-9.7 kcal.mol−1, RMSD=0.95 Å and the site-site distance between –OH and Glu 208 is 1.77 Å. TA10-SARS-CoV-2 has DS=-9.2 kcal.mol−1, RMSD=2.75 Å and site-site distance between –OH with Gln 189 is 2.90 Å. DS and RMSD of TA18-ACE2 are bit larger than those of TA18-SARS-COV-2. An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various influenza and coronaviruses. A clearly time-dependent antiviral activity for Olbas and cajuput oil could be demonstrated. Prevention and treatment information (HHS). Freshcare hot / strong is suitable for use after heavy activity and is suitable for hotter fans. Cajaput oil is used as an expectorant, for treatment of tooth and gum pain, and for its antiseptic properties. Further information of the ACE2 and PDB6LU7 proteins can be found at UniProtKB15 and Worldwide Protein Data Bank,16 respectively. Pretreatment of the Vero cells prior to virus addition or posttreatment with 0.1% TTO after viral absorption did not significantly alter plaque formation. The anti-SARS-CoV-2 and anti-ACE2 activities of the cajuput essential oil composition into the PDB6LU7 and ACE2 proteins are shown in the following order: TA1 > TA3 > TA4 > TA7. Lonalool (TA19) is capable of binding to ACE2 and PDB6LU7 proteins and has quite good interactions with amino acid Asn 210 of ACE2 protein, and Gly 143 as well as Cys 145 of PDB6LU7 protein (Table 2 and Figure 2): v) Docking of TA19-ACE2 has DS=-10.9 kcal.mol−1, RMSD=1.77 Å, and site-site bonding interaction between –OH and amino acid Asn 210 is 1.96 Å. vi) Docking of TA19-SARS-CoV-2 has DS of −11.1 kcal.mol−1, and RMSD of 1.18 Å, and site-site bonding interactions between –OH and amino acid Gly 143 and Cys 145 are 2.89 Å and 2.82 Å, respectively. This is important in discovering medicinal herbs and developing treatments to prevent the SARS-CoV-2 pandemic.16. It helps reduce stress, inhibit cancer cells, and fight inflammation.21 Moreover, TA19 is also a major ingredient in some essential oils and used as aroma to produce perfumes, pharmaceuticals, and cosmetics.21, Figures 3 and 4, and Table 3 present the docking results of ACE2 and PDB6LU7 proteins by Cineol (TA1), β-Selinenol (TA3), α-Eudesmol (TA4), and γ-Eudesmol (TA7). b. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Use as a tonic. Also known as Cajuput, Melaleuca leucadendron, Melaleuca minor, Paperbark Tree, Punk Tree, White Wood. Epub 2007 Oct 31. The inhibitory capability of active compounds in the TA from Thua Thien Hue, Vietnam over the Angiotensin-Converting Enzyme 2 (ACE2) protein in human body - the host receptor for SARS-CoV-2 and the main protease (PDB6LU7) of the SARS-CoV-2 using docking simulation has been studied herein. It is found that Terpineol (TA2), Guaiol (TA5), and Linalool (TA19) are the best 3 compounds to have the binding ability toward the ACE2 and PDB6LU7 proteins with lots of convergence points and the inhibitory intensity of these compounds on ACE2 and PDB6LU7 proteins is almost similar (Table 2 and Figure 2).
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